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BRCA1 Is a Gene Involved in Repair of Double-Stranded DNA

Question 44

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BRCA1 is a gene involved in repair of double-stranded DNA breaks.Mutant forms of this gene are linked to a substantial proportion of familial breast cancers.A woman who inherits a certain allele of the gene has about a 60-80% chance of getting breast cancer,as well as an elevated chance of getting ovarian cancer,in her lifetime.
a.Why don't a higher percentage of women with the mutation get breast cancer?
b.How would the breast cancer inheritance caused by BRCA1 be described in Mendelian terms?

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(a)BRCA1 is a tumor suppressor gene.Tumo...

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