First attempts to develop cholesterol-lowering drugs targeted the later steps in cholesterol biosynthesis. Why did this strategy have to be abandoned?
A) These reactions were so efficient that they could not be blocked.
B) The accumulation of an insoluble substrate caused cataracts and other deleterious side effects.
C) All of the drugs that were developed actually enhanced cholesterol synthesis.
D) None of the drugs that were developed could survive the acid conditions in the stomach.
E) These drugs caused untreatable gall stones.

Question

Quizplus · Accepted Answer

The strategy had to be abandoned because blocking the later steps in cholesterol biosynthesis led to the accumulation of an insoluble substrate, which caused cataracts and other deleterious side effects.

First Attempts to Develop Cholesterol-Lowering Drugs Targeted the Later Steps