Which of the following drugs were developed as a result of information obtained from a mouse model that had the gene that normally produces the α-subunit of the H⁺, K⁺ ATPase transport system "knocked out"? A) Prilosec and Prevacid B) Celebrex and Viox C) Crixivan D) Lipitor and Crestor E) Viagra

Question

Quizplus · Accepted Answer

Prilosec (omeprazole) and Prevacid (lansoprazole) are proton pump inhibitors (PPIs) that were developed to inhibit the H+/K+ ATPase in the gastric parietal cells, reducing stomach acid secretion. This mechanism is closely related to the information obtained from mouse models with a specific gene knockout affecting an ATPase transport system, which provided insights into the regulation of acid secretion and contributed to the development of these drugs.

Which of the Following Drugs Were Developed as a Result