An integrating center of a negative feedback loop has the function of analyzing information from many different sensors about deviations from a set point and then altering the activity of particular effectors to compensate for the deviation.

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This is the definition of an integrating center in a negative feedback loop. It is responsible for processing sensory information and modifying the activity of effectors to return the system to its set point.

An Integrating Center of a Negative Feedback Loop Has the Function