Which of the following may explain why self-tolerance may fail?
A)A non-circulating antigen becomes exposed to the immune system.
B)Antibodies directed against other antibodies are produced.
C)Antibodies produced against foreign antigens cross-react with self-antigens.
D)All of the choices are correct.

Question

Quizplus · Accepted Answer

All of these choices can contribute to the failure of self-tolerance. A non-circulating antigen may become exposed to the immune system through an infection or injury. Antibodies directed against other antibodies can occur in autoimmune diseases where the immune system attacks certain types of antibodies. Cross-reactivity between foreign and self-antigens can lead to the immune system attacking healthy tissues mistaken for foreign invaders.

Which of the Following May Explain Why Self-Tolerance May Fail