Water-soluble hormones bind to receptors located within the plasma membrane.

Question

Quizplus · Accepted Answer

Water-soluble hormones, such as peptide hormones, bind to receptors located within the plasma membrane because they cannot cross the hydrophobic lipid bilayer of the membrane. Once the hormone binds to the receptor, it triggers a signaling cascade inside the cell. In contrast, lipid-soluble hormones, such as steroid hormones, can diffuse across the membrane and bind to intracellular receptors located in the cytoplasm or the nucleus.

Water-Soluble Hormones Bind to Receptors Located Within the Plasma Membrane