Stomach irritation by NSAIDs like aspirin is believed to be the result of A)inhibition of PGI₂ and PGE₂. B)secretion of PGI₂ and PGE₂. C)inhibition of thromboxane A₂. D)None of the choices are correct.

Question

Quizplus · Accepted Answer

NSAIDs like aspirin inhibit the enzymes cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), which are responsible for the production of prostaglandins (PGs) and thromboxane (TXA2) from arachidonic acid. Inhibition of COX-1, which is constitutively expressed in the stomach, leads to a decrease in the production of protective PGs like prostacyclin (PGI2) and prostaglandin E2 (PGE2). This imbalance between protective and damaging PGs can cause stomach irritation and ulcers. Therefore, the correct answer is A - inhibition of PGI₂ and PGE₂.

Stomach Irritation by NSAIDs Like Aspirin Is Believed to Be