Fatigue appears to occur due to the reduced ability of the sarcoplasmic reticulum release of Ca²⁺ with neural stimulation.

Question

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The reduced ability of the sarcoplasmic reticulum to release Ca2+ with neural stimulation is a known contributor to muscle fatigue. This decrease in Ca2+ release affects the ability of muscle fibers to contract and results in a feeling of tiredness or weakness.

Fatigue Appears to Occur Due to the Reduced Ability of the Sarcoplasmic