Elevated secretion of ACTH,as in Addison's disease,causes a darkening of the skin because ACTH is related to MSH which causes production of the pigment melanin.

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Elevated secretion of ACTH can cause a darkening of the skin, known as hyperpigmentation, because ACTH is related to MSH (melanocyte-stimulating hormone) which stimulates the production of melanin, the skin pigment that gives color to our skin, hair, and eyes. In Addison's disease, there is a deficiency of cortisol and aldosterone, which leads to an increase in ACTH secretion by the pituitary gland in an attempt to stimulate the adrenal glands to produce more hormones. This excess ACTH can stimulate the melanocytes in the skin to produce more melanin, leading to hyperpigmentation, especially in areas exposed to sunlight or friction.

Elevated Secretion of ACTH,as in Addison's Disease,causes a Darkening of the Skin