Sympathetic and parasympathetic neurons generally release different neurotransmitters to their smooth muscle effector cells,which is why these neurons often have antagonistic effects.

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Sympathetic neurons typically release norepinephrine, while parasympathetic neurons typically release acetylcholine. These two neurotransmitters can have opposing effects on smooth muscle, leading to the antagonistic effects of sympathetic and parasympathetic stimulation.

Sympathetic and Parasympathetic Neurons Generally Release Different Neurotransmitters to Their