Almost all of the earliest U.S.cities west of the Appalachians were

Name: Almost all of the earliest U.S.cities west of the Appalachians were
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The earliest U.S. cities west of the Appalachians were often located along major waterways, such as rivers or lakes, as they provided access to transportation and trade opportunities. Cities such as St. Louis and New Orleans, both founded in the 1700s, were established on the Mississippi River and became important trading centers.

Almost All of the Earliest U