A large animal will have difficulty with respiration and digestion unless its body surface invaginates or it develops an internal transport system.
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This statement is true. A large animal's body surface area will not be able to efficiently exchange gases or absorb nutrients without either invaginations (such as lungs or a digestive system) or an internal transport system (such as a circulatory system).

A Large Animal Will Have Difficulty with Respiration and Digestion