Why would you expect acyclovir to be ineffective against latent HSV infections?
A) This is an antibacterial drug, and HSV is a virus.
B) This is an antifungal drug, and HSV is a virus.
C) This drug directly inhibits DNA polymerase activity-cells that are latently infected with HSV have no DNA polymerase activity.
D) This drug is a nucleoside analogue-it becomes activated by a viral enzyme that is produced only when the virus is replicating. As such, if the virus is latent, the enzyme to activate the drug is not present (and the drug is ineffective) .
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