In fifteenth-century Europe,localities could expect a renewed outbreak of plague:

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The Black Death pandemic in the mid-1300s killed an estimated 30-50% of Europe's population. However, even after the initial outbreak, bubonic plague continued to resurface in Europe. Historical records suggest that major outbreaks of plague occurred around every 10 years in the fifteenth century, including the outbreaks of 1448, 1456-57, 1464-65, 1478-79, and 1489-90. While there were certainly smaller outbreaks in between, the major recurring epidemics happened on this approximate decade-long cycle.

In Fifteenth-Century Europe,localities Could Expect a Renewed Outbreak of Plague