The most obvious depletion of the ozone layer has occurred over

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The most significant depletion of the ozone layer has occurred over Antarctica, known as the "ozone hole." This phenomenon is caused by the presence of human-made chemicals, such as chlorofluorocarbons (CFCs), which react with ozone molecules in the atmosphere and break them down. While there have been some localized ozone depletion events in other areas, such as the Arctic and parts of the mid-latitudes, the Antarctic ozone hole remains the most significant and well-known example.

The Most Obvious Depletion of the Ozone Layer Has Occurred