Specific immune responses differ from nonspecific ones in that the former are mediated by lymphocytes.

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Specific immune responses are mediated by lymphocytes, while nonspecific ones are not. Nonspecific responses are general and primarily involve physical and chemical barriers such as skin and mucous membranes, as well as immune cells that engulf and destroy invading pathogens. Specific responses involve T and B lymphocytes that specifically recognize and target particular pathogens, resulting in long-term immunity.

Specific Immune Responses Differ from Nonspecific Ones in That the Former