At the end of pregnancy,the uterus becomes responsive to stimuli to which it was previously refractory because

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The ratio of progesterone to estrogen decreases at the end of pregnancy, which allows the uterus to become more responsive to stimuli that it was previously refractory to. Progesterone acts to inhibit the contraction of the uterus, while estrogen stimulates the contraction. As the ratio of progesterone to estrogen decreases, the uterus becomes more sensitive to the stimulatory effects of estrogen, leading to contractions and eventually labor.

At the End of Pregnancy,the Uterus Becomes Responsive to Stimuli