If a tissue increases its metabolism enough to drop its interstitial $P _ { o _ { 2 } }$ to half the resting venous value,the amount of O₂ available from oxyhemoglobin will be more than twice that for the resting tissue.

Question

Quizplus · Accepted Answer

When the tissue increases its metabolism, it requires more oxygen and produces more carbon dioxide, leading to a decrease in interstitial $P _ { o _ { 2 } }$ and an increase in interstitial $P _ { c _ { o _ { 2 } } }$. The lower interstitial $P _ { o _ { 2 } }$ causes more oxygen to be released from oxyhemoglobin, resulting in an increase in the amount of oxygen available to the tissue. According to the oxygen-hemoglobin dissociation curve, when interstitial $P _ { o _ { 2 } }$ is half the resting venous value, the percent saturation of hemoglobin with oxygen is approximately 75%, which is more than twice the percent saturation at rest. Therefore, the amount of oxygen available from oxyhemoglobin will be more than twice that for the resting tissue.

If a Tissue Increases Its Metabolism Enough to Drop Its Po2P _ { o _ { 2 } }Po2​​

If a Tissue Increases Its Metabolism Enough to Drop Its $P _ { o _ { 2 } }$