In the clotting cascade,an enzyme activated toward the end of the cascade inhibits its own activation.

Question

Quizplus · Accepted Answer

The enzyme activated toward the end of the clotting cascade is called thrombin. Thrombin is involved in converting fibrinogen to fibrin, ultimately leading to clot formation. However, thrombin also activates a protein called protein C, which, when activated, inhibits the activity of both thrombin and factors VIIIa and Va, thus effectively downregulating the clotting cascade to prevent excessive and unwanted clot formation. Therefore, the statement is true.

In the Clotting Cascade,an Enzyme Activated Toward the End of the Cascade