A brain difference between left-handers and right-handers is that

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Studies have shown that left-handers have a greater ability to imagine and manipulate spatial layouts in their minds, possibly due to more extensive connections between the two hemispheres of their brain, which is thought to be one of the benefits of being left-handed. There is no conclusive evidence suggesting that left-handers have less myelination or that right-handers have slower prefrontal lobe development. While left-handers may have some differences in language processing, it is not necessarily more diverse than that of right-handers.

A Brain Difference Between Left-Handers and Right-Handers Is That