According to the Food Additives Amendment of 1958,

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The Food Additives Amendment of 1958 placed additives that were in use and deemed safe prior to 1958 on the GRAS (Generally Recognized as Safe) list, meaning that they did not need to be tested for safety. However, new additives still needed to be tested for safety before being approved for use in food. The Delaney Clause, which prohibited the approval of any additive that caused cancer in humans or animals, was not part of the Amendment but was a separate provision in the same law.