Microbes have been major selective agents for humans, particularly before the arrival of modern medicine.

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Before modern medicine, infectious diseases caused by microbes had a significant impact on human survival and reproduction. This meant that individuals who had genetic variations that allowed them to be more resistant to certain infectious diseases were more likely to survive and pass on their genes to their offspring. Therefore, microbes played a key role as selective agents in shaping human evolution.

Microbes Have Been Major Selective Agents for Humans, Particularly Before