The first single-gene disorder for which the mechanism of mutation was understood at a molecular level was
A)cystic fibrosis.
B)hemophilia.
C)sickle cell disease.
D)diabetes mellitus.

Question

Quizplus · Accepted Answer

The first single-gene disorder for which the mechanism of mutation was understood at a molecular level was sickle cell disease. In 1949, Vernon Ingram discovered that the disease was caused by a single amino acid substitution in the beta globin chain of hemoglobin. This was the first demonstration that a single nucleotide change in the DNA could cause a genetic disease.

The First Single-Gene Disorder for Which the Mechanism of Mutation