The middle layer of the wall of an artery or vein is made up of:

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The middle layer of the wall of an artery or vein, also known as the tunica media, is composed of smooth muscle cells. These cells are responsible for regulating the diameter of the blood vessel and controlling blood flow. Connective tissue is found in the outer layer (tunica adventitia) and skeletal muscle is not found in blood vessels. Endothelium and simple squamous epithelial cells form the inner lining (tunica intima) of the blood vessel.

The Middle Layer of the Wall of an Artery or Vein