A karyotype is produced by inducing cells to divide in culture and then treating the cells with a drug that halts mitosis in:

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This is because a karyotype is prepared by photographing the chromosomes when they are highly condensed, which only occurs during metaphase, where the chromosomes are all aligned at the equator of the cell. The drug used to halt mitosis is colchicine or another spindle inhibitor, which is added when the cells are at metaphase. This allows the chromosomes to remain in place, rather than moving to the poles of the cell during anaphase.

A Karyotype Is Produced by Inducing Cells to Divide in Culture