Tay-Sachs disease is a neurological disorder in which a defective enzyme prohibits the breakdown of phospholipids called gangliosides.Where would gangliosides accumulate?

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Gangliosides would accumulate in membranes. This is because gangliosides are a type of phospholipid that are typically found in cellular membranes, especially those of nerve cells. In Tay-Sachs disease, the defective enzyme prevents the breakdown of gangliosides, leading to their accumulation in the membranes of nerve cells in the brain and spinal cord, causing neurological problems.

Tay-Sachs Disease Is a Neurological Disorder in Which a Defective