Which of the following would provide the longest lasting treatment for adenosine deaminase (ADA)deficiency?
A) injecting PEG-ADA purified from a cow
B) injecting white blood cells genetically modified to carry functional ADA genes
C) supplying progenitor T cells genetically modified to carry functional ADA genes shortly after birth
D) using siRNA to knockdown ADA genes
E) using cDNA to produce ADA in E. coli

Question

Which of the following would provide the longest lasting treatment for adenosine deaminase (ADA)deficiency?
A) injecting PEG-ADA purified from a cow
B) injecting white blood cells genetically modified to carry functional ADA genes
C) supplying progenitor T cells genetically modified to carry functional ADA genes shortly after birth
D) using siRNA to knockdown ADA genes
E)  using cDNA to produce ADA in E. coli

Quizplus · Accepted Answer

Supplying progenitor T cells genetically modified to carry functional ADA genes shortly after birth would provide the longest lasting treatment for ADA deficiency. This is because progenitor T cells are able to differentiate into various immune cells including T cells, B cells, and natural killer cells, which can produce ADA proteins. Therefore, this treatment can provide long-term production of ADA proteins in the patient's immune system.

Which of the Following Would Provide the Longest Lasting Treatment