Deleterious alleles are eliminated from populations by

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Deleterious alleles reduce fitness, making individuals with those alleles less likely to survive and reproduce. This reduces the frequency of those alleles in the population over time, which is the result of natural selection. Mutations can introduce deleterious alleles into a population, migration can introduce or remove alleles from a population (which may or may not be deleterious), nonrandom mating can affect allele frequencies, and genetic drift can lead to the random loss or fixation of alleles (including deleterious ones). However, natural selection is the most direct and effective mechanism for eliminating deleterious alleles from populations.

Deleterious Alleles Are Eliminated from Populations by