The frequency of the allele that causes sickle cell disease is higher in some populations than in others because

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The allele that causes sickle cell disease is higher in populations where malaria is more prevalent. This is because heterozygotes (who carry one copy of the sickle cell allele) are more resistant to malaria, giving them a selective advantage in regions where malaria is common. Over time, this can lead to higher frequencies of the sickle cell allele in these populations. The other choices are not related to the frequency of the sickle cell allele.

The Frequency of the Allele That Causes Sickle Cell Disease