In Huntington disease,the mutation causes the encoded protein to have a novel function from the wild type protein.This is an example of
A) a gain of function.
B) a loss of function.
C) a translocation of function.
D) a deletion.
E) a change in the genetic code.

Question

Quizplus · Accepted Answer

In Huntington disease, the mutation causes the huntingtin protein to have a novel function that is not present in the wild type protein. Specifically, the mutated huntingtin protein has a longer polyglutamine tract than the wild type protein, which leads to the production of toxic protein aggregates that eventually cause neuronal cell death. This novel function represents a gain of function, as the mutated protein has acquired a new property that is not present in the wild type protein.

In Huntington Disease,the Mutation Causes the Encoded Protein to Have