A missense mutation causes sickle cell disease by

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A missense mutation is a type of point mutation where the change in the DNA sequence results in a different amino acid being incorporated into the protein. In the case of sickle cell disease, the missense mutation affects the beta globin gene, resulting in a change of a single amino acid in the hemoglobin protein. This causes the hemoglobin to form abnormal fibers, resulting in red blood cells that are sickle-shaped and less able to carry oxygen. Therefore, the altered protein's shape affects its function, leading to sickle cell disease.

A Missense Mutation Causes Sickle Cell Disease by