In hereditary spherocytosis,red blood cells lose their doughnut shapes,ballooning out,because they have abnormal

Question

Quizplus · Accepted Answer

Hereditary spherocytosis is caused by a mutation in genes that encode for proteins involved in the structure of red blood cells, such as ankyrin, spectrin, and other proteins. Ankyrin is responsible for binding spectrin rods to the plasma membrane, and a mutation in this protein can lead to weakened connections between the cytoskeleton and plasma membrane, causing the characteristic shape changes seen in hereditary spherocytosis. Microtubules, microfilaments, CFTR proteins, and hemoglobin are not directly involved in the structure of red blood cells and are not affected by this disease.

In Hereditary Spherocytosis,red Blood Cells Lose Their Doughnut Shapes,ballooning Out,because