A genetic disorder found most commonly in African Americans, Africans, and some Mediterranean populations which is characterized by the production of abnormal hemoglobin causing RBCs to change shape is:

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Sickle cell anemia is a genetic disorder that is most commonly found in African Americans, Africans, and some Mediterranean populations. It is characterized by the production of abnormal hemoglobin, causing red blood cells to change shape and become sickle-shaped. This can lead to blockages in blood vessels, decreased oxygen to tissues, and severe pain.

A Genetic Disorder Found Most Commonly in African Americans, Africans