What happens to the four globin chains when hemoglobin is broken down by the liver and spleen?

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The liver and spleen function to remove old, worn out red blood cells. These two organs break down the cells and process the hemoglobin. In both organs, hemoglobin is broken down to heme and globin. Globin is the four chains of amino acids. The chains are broken down to free amino acids, which are then recycled to the red bone marrow. These are the exact amino acids that will be needed later to form new hemoglobin during erythropoiesis. The heme is further broken down to iron (recycled to the red bone marrow) and bilirubin (a waste that must be removed from the body). The liver secretes bilirubin in bile, a digestive juice. Bilirubin is then removed from the body with feces. The spleen secretes bilirubin into the blood for the kidney to remove and put in urine.

What Happens to the Four Globin Chains When Hemoglobin Is