Metabolically active tissues have which of the following sets of conditions that shift the oxyhemoglobin dissociation curve to the right?
A)$\uarr$PO2, $\darr$ PCO2, $\uarr$ temperature, $\uarr$ BPG
B)$\darr$ PO2, $\uarr$ PCO2, $\uarr$ temperature, $\uarr$ BPG
C)$\darr$ PO2, $\uarr$ PCO2, $\darr$ temperature, $\uarr$ BPG
D)$\uarr$ PO2, $\darr$ PCO2, $\uarr$ temperature, $\darr$ BPG

Question

Quizplus · Accepted Answer

Metabolically active tissues have a higher demand for oxygen and produce more CO2 and acid which causes the oxyhemoglobin dissociation curve to shift to the right. This means that at any given PO2, there is a decrease in the affinity of hemoglobin for oxygen allowing for easier unloading of oxygen to the tissue. BPG (2,3-bisphosphoglycerate) also contributes to this shift. Therefore, the correct set of conditions that shift the oxyhemoglobin dissociation curve to the right are: decreased PO2, increased PCO2, increased temperature, and increased BPG; which is only present in choice B.

Metabolically Active Tissues Have Which of the Following Sets of Conditions