The significance of the Griffith,Avery and Hershey-Chase experiments was that they demonstrated that:

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The Griffith, Avery, and Hershey-Chase experiments helped to establish that DNA was the molecule of heredity. Each experiment contributed to this conclusion in different ways, but their combined results provided strong evidence that DNA, and not proteins or other molecules, carried the genetic information necessary for inheritance.

The Significance of the Griffith,Avery and Hershey-Chase Experiments Was That