The enzyme that joins the ends of newly synthesized segments of DNA after the primers have been removed is:

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DNA ligase is responsible for joining or connecting the Okazaki fragments and making them into a single continuous strand of DNA. DNA ligase works by catalyzing the formation of a phosphodiester bond between the 3' hydroxyl group of the adjacent nucleotide and the 5' phosphate group of the DNA strand. This process completes the synthesis of the lagging strand during DNA replication. DNA polymerase extends the primers, but DNA ligase is needed to connect them. Helicase unwinds the double helix for replication, primase synthesizes RNA primers, and RNA ligase is not a known enzyme.

The Enzyme That Joins the Ends of Newly Synthesized Segments