Studies of phenylketonuria (PKU) provide particularly strong evidence for the conclusion that

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PKU is a genetic condition caused by a mutation in the gene that codes for the enzyme phenylalanine hydroxylase. This enzyme is responsible for breaking down the amino acid phenylalanine. Without the enzyme, phenylalanine builds up in the body and can cause intellectual disability and other neurological problems. However, PKU can be managed by controlling the intake of phenylalanine through diet, and many children with PKU who follow a strict diet can avoid the symptoms of the condition. This demonstrates that changes in the environment (in this case, through diet) can alter the outcome of a condition that is under genetic control.

Studies of Phenylketonuria (PKU) Provide Particularly Strong Evidence for the Conclusion