Nearly all medical and recreational drugs that modify people's experiences exert their effects at

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Nearly all drugs that modify people's experiences exert their effects at synapses, which are the junctions between neurons where chemical signals are transmitted. Drugs can either increase or decrease the release or uptake of neurotransmitters, leading to changes in mood, perception, and behavior. Blood vessels and hormonal glands may be affected by certain drugs, but these are secondary or indirect effects. Sensory receptors are not the primary target for most drugs, although some drugs (e.g. local anesthetics) may act on these receptors to produce their effects.

Nearly All Medical and Recreational Drugs That Modify People's Experiences