One problem that needs to be explained if schizophrenia does have a genetic basis is,

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If schizophrenia has a genetic basis, then natural selection should have eliminated the gene, as schizophrenia is associated with reduced fertility and increased risk of early death. However, the fact that the gene persists suggests that it may confer some evolutionary advantage, or that it may be genetically linked to other traits that are beneficial.

One Problem That Needs to Be Explained If Schizophrenia Does