The same hormone has considerably different effects in different species. The hormone thyroxin in humans stimulates metabolism, but in frogs it induces metamorphosis from tadpole to adult frog. This indicates that

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The fact that thyroxin has different effects in humans and frogs suggests that the target tissues (i.e. the cells that thyroxin acts upon) in these two species have evolved different responses to the hormone. This is a common phenomenon in biology, where different species have evolved different physiological mechanisms and adaptations to suit their specific needs and environments.

The Same Hormone Has Considerably Different Effects in Different Species