T cells that respond against self-antigens are inactivated by:

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T cells that respond against self-antigens are inactivated by apoptosis. This is a process of programmed cell death that eliminates self-reactive T cells during development in the thymus, called negative selection. This helps prevent autoimmunity by eliminating T cells that could potentially attack self-tissues. Binding to immunoglobulin (A) is a feature of B cells, not T cells, and is not involved in regulating self-reactivity. Intermediate-strength binding to self MHC (B) is involved in positive selection, which occurs during T cell development and ensures that T cells are able to recognize and respond to peptide-MHC complexes presented by self cells. This process helps ensure that the T cell population has sufficient diversity and is functional for defending against pathogens.

T Cells That Respond Against Self-Antigens Are Inactivated By