Antigen-independent differentiation of B cells occurs in the:

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Antigen-independent differentiation of B cells occurs in the bone marrow, where they undergo various stages of development and maturation, including gene rearrangement, selection, and proliferation. This process gives rise to mature naive B cells, which are capable of recognizing and responding to specific antigens. The spleen, lymph nodes, and Peyer's patches are all sites where B cells may encounter and respond to antigens after they have matured in the bone marrow.

Antigen-Independent Differentiation of B Cells Occurs in The