Immunoglobulins are grouped into classes on the basis of similarities in:

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Immunoglobulins are grouped into classes based on similarities in their heavy chains, which determine their effector functions and tissue distribution. For example, IgG has a gamma heavy chain and is the most abundant antibody in serum, while IgE has an epsilon heavy chain and is associated with allergic responses. Differences in the variable regions of the heavy and light chains determine the antigen-binding specificity of each immunoglobulin.

Immunoglobulins Are Grouped into Classes on the Basis of Similarities