Why Is Sickle Cell Disease More Common in Americans with African

Why is sickle cell disease more common in Americans with African ancestors than Americans with European ancestors?

A) Sickle-shaped blood cells caused malarial parasites to die,and thus gave protection against malarial infections prevalent in AfricA.
B) Sickle-shaped blood cells were good hosts for tuberculosis,and thus spread tuberculosis widely throughout Africa.
C) Sickle-shaped blood cells caused cholera bacteria to die,and thus gave protection against large-scale cholera epidemics throughout Europe.
D) Sickle-shaped blood cells caused tuberculosis bacteria to die,and thus gave protection against large-scale Tb epidemics throughout crowded areas in Africa.
E) Sickle-shaped blood cells were good hosts for cholera bactera,and thus caused many people to die from cholera and diarrhea.