A 10-year-old girl visits her physician's office because she has been complaining about being thirsty and having to go to the bathroom all the time.She has lost 15 pounds over the past 6 months and has been more irritable than usual,especially after meals.The girl's fasting blood glucose is 575 mg/dL (reference range,

Question

A 10-year-old girl visits her physician's office because she has been complaining about being thirsty and having to go to the bathroom all the time.She has lost 15 pounds over the past 6 months and has been more irritable than usual,especially after meals.The girl's fasting blood glucose is 575 mg/dL (reference range,< 100 mg/dL),her C-peptide is 0.5 ng/mL (reference range,0.8-3.1 ng/mL),and she has autoantibodies against glutamic acid decarboxylase and insulin.On the basis of these findings,a likely diagnosis for this girl is:

Quizplus · Accepted Answer

The symptoms described in the case, including increased thirst, frequent urination, weight loss, irritability after meals, and high fasting blood glucose levels, are indicative of type 1 diabetes. The low C-peptide levels and presence of autoantibodies against glutamic acid decarboxylase and insulin further support this diagnosis. Hashimoto's thyroiditis, acute glomerulonephritis, and progressive systemic sclerosis do not typically present with these symptoms or laboratory findings.

A 10-Year-Old Girl Visits Her Physician's Office Because She Has