A 9-month-old boy is suspected of having an immune deficiency because he had many recurrent infections with Streptococcus pneumoniae.Laboratory tests reveal a normal percentage of T cells and T-cell subsets but a lack of mature B cells and immunoglobulins.This boy most likely has:

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The lack of mature B cells and immunoglobulins points to a defect in antibody production, which is characteristic of X-linked agammaglobulinemia. Wiskott-Aldrich syndrome is characterized by eczema, thrombocytopenia, and recurrent infections. DiGeorge anomaly typically presents with low T cell counts and cardiac anomalies. Chronic granulomatous disease presents with recurrent bacterial and fungal infections due to impaired phagocyte function.

A 9-Month-Old Boy Is Suspected of Having an Immune Deficiency