The buildup of toxic purine metabolites that impair B- and T-cell proliferation is the result of a mutation in the gene coding for:

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The buildup of toxic purine metabolites that impair B- and T-cell proliferation is the result of a mutation in the gene coding for adenosine deaminase (ADA). ADA is responsible for breaking down adenosine and deoxyadenosine into inosine and deoxyinosine, respectively. In the absence of ADA, these purine metabolites accumulate, leading to cytotoxicity and impaired lymphocyte development.

The Buildup of Toxic Purine Metabolites That Impair B- and T-Cell