The pathogenesis of Rocky Mountain spotted fever involves:

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The pathogenesis of Rocky Mountain spotted fever involves damage to endothelial cells, which leads to increased vascular permeability and subsequent hypovolemia, edema, and hypotension. This damage is caused by the organism's ability to invade and replicate within these cells, ultimately leading to their destruction. This damage to the endothelium is the main cause of the clinical symptoms and complications of the disease. Systemic release of cytokines and exotoxins also contribute to the pathogenesis, but endothelial cell damage is the key factor. Invasion of the organism into the cardiac muscle does not play a significant role in the pathogenesis of Rocky Mountain spotted fever.

The Pathogenesis of Rocky Mountain Spotted Fever Involves