How does pH alter an enzymatic reaction rate?

Question

Quizplus · Accepted Answer

pH can affect the ionization state of key amino acids in the enzyme protein at the active center and other sites, which can alter the enzyme's ability to bind to the substrate and catalyze the reaction. This can ultimately affect the rate of enzymatic reaction. Option B is incorrect because thermal inactivation is not directly related to pH. Option C may be true for some enzymes, but it is not a general rule. Option D is not a valid statement because decreasing the K_m would increase the affinity of the enzyme for the substrate, but it would not necessarily increase the rate of the reaction.

How Does PH Alter an Enzymatic Reaction Rate